Hyaluronidase is an enzyme that breaks down hyaluronic acid, a substance commonly used in dermal fillers. It is injected directly into areas where filler has been placed to dissolve or reduce the filler, either partially or completely. The procedure is used when a patient wishes to reverse or adjust a previous filler treatment, correct an undesired result, or address complications from filler placement.

Hyaluronidase is suitable for people who have received hyaluronic acid-based dermal fillers and wish to have them removed or reduced. It may be chosen by those who are dissatisfied with filler results, experience asymmetry or overcorrection, or want to reverse filler before trying a different approach. A qualified provider will assess the extent of filler and determine whether this treatment is appropriate.

The procedure involves injections of hyaluronidase into the areas containing filler. Most patients describe the experience as similar to receiving filler injections themselves. The appointment typically takes 15 to 30 minutes, depending on the volume of filler being addressed.

There is generally no downtime associated with hyaluronidase injections. Some patients may experience mild swelling or bruising at injection sites, which typically resolves within a few days. Normal activities can usually be resumed immediately.

Hyaluronidase begins breaking down filler within hours and the effect is usually visible within 24 to 48 hours. Complete dissolution of filler may take several days. Results are considered permanent in terms of filler removal, though the underlying skin structure may require future treatment depending on individual goals.